FIGURE 2.

Schematic diagram of gene regulation and protein interactome networks of BRD4. (A) Schematic diagram of BRD4 gene-regulatory networks. (B) Schematic diagram of BRD4 interactome. BCL2, B-cell lymphoma 2; BD2, bromodomain 2; BID, basic residue-enriched interaction domain; BRD2, bromodomain-containing protein 2; BRD3, bromodomain-containing protein 3; BRD4, bromodomain-containing protein 4; BRD8, bromodomain-containing protein 8; BRDT, bromodomain testis-specific protein; BRPF3, bromodomain and PHD finger-containing protein 3; CAMKK2, calcium/calmodulin-dependent protein kinase kinase 2; CCL2, C-C motif chemokine ligand 2; CCNT1, cyclin T1; CDH15, cadherin 15; C-MYC, myelocytomatosis viral oncogene cellular homolog; CDK9, cyclin-dependent kinase 9; CK2, casein kinase II; DDX18, DEAD-box helicase 18; E2F, early 2 factor; FOSL1, fos like 1; GAS7, growth arrest specific 7; GREB1, growth regulating estrogen receptor binding 1; HMOX1, heme oxygenase 1; HTRA1, HtrA serine peptidase 1; IGFBP1, insulin-like growth factor-binding protein 1; IL-2, interleukin-2; IL-8, interleukin-8; INO80B, INO80 complex subunit B; KDM1B, lysine demethylase 1B; KEAP1, Kelch-like ECH-associated protein 1; KMT5B, lysine methyltransferase 5B; MYCN, myelocytomatosis viral oncogene neuroblastoma-derived homolog; NAA35, N-alpha-acetyltransferase 35; NPM1, nucleophosmin1; NPS, N-terminal cluster of CK2 phosphorylation sites; NRF2, nuclear factor erythroid 2-related factor 2; NSD2, nuclear receptor binding SET domain protein 2; NSD3, nuclear receptor binding SET domain protein 3; PSA, puromycin-sensitive aminopeptidase; P-TEFb, positive transcription elongation factor b; RFC3, replication factor C subunit 3; ROS, reactive oxygen species; SP110, SP110 nuclear body protein; TEX43, testis-expressed 43; TFF1, trefoil factor 1; ZNF740, zinc finger protein 740