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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Med Res Rev. 2021 Oct 11;42(2):710–743. doi: 10.1002/med.21859

FIGURE 4.

FIGURE 4

Development of dual-target inhibitors of BET bromodomains and PLK1. (A) X ray cocrystal structure of BI-2536 bound to BRD4(1) (PDB ID: 4O74). (B) X ray cocrystal structure of BI-2536 bound to PLK1 (PDB ID: 2RKU). (C) SARs of BI-2536. Protein is represented by gray ribbons with key compound-contacting residues highlighted in yellow sticks. The compound is shown in sticks and colored according to the atom type (C, light blue; N, blue; O, red). Black dashed line = hydrogen bond; orange sphere = water molecule