Skip to main content
. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Med Res Rev. 2021 Oct 11;42(2):710–743. doi: 10.1002/med.21859

FIGURE 7.

FIGURE 7

Development of dual inhibitors of BET bromodomains and JAK2. (A) Chemical structures of TG101348 and TG101209. (B) X ray cocrystal structure of TG101348 bound to BRD4(1) (PDB ID: 4OGJ). (C) SARs of dual inhibitors of BET bromodomains and JAK2. Protein is represented by gray ribbons, with key compound-contacting residues indicated by yellow sticks. The compound is shown in sticks and colored according to the atom type (C, light blue; N, blue; O, red; S, yellow). Black dashed line = hydrogen bond; orange sphere = water molecule