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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Mol Psychiatry. 2021 Aug 12;27(1):436–444. doi: 10.1038/s41380-021-01253-4

Figure 3. Schematic diagram of the operant progressive ratio (PR) task.

Figure 3.

In this task mice press a lever an increasing number of times to earn food reinforcement (left). In this example, the lever press requirement is doubled after each reinforcer earned (bottom). The D2R-OE transgenic mice show reduced cumulative survival (proportion of mice that are still pressing the lever as a function of session time) compared to wildtype littermates or D2R-OE mice treated with doxycycline (Dox) to switch off the transgene (Right).