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. Author manuscript; available in PMC: 2022 Jul 1.
Published in final edited form as: Mol Psychiatry. 2021 Aug 12;27(1):436–444. doi: 10.1038/s41380-021-01253-4

Table 1.

A summary of the effect on performance in a food reinforced progressive ratio schedule of various manipulations to dopamine D2 receptors or dopamine neurons. NAc (nucleus accumbens), CPu (caudate putamen), SPNs (spiny projection neurons), βarr (βarrestin biased).

PR Type of manipulation Region Cell-type D2R Citation
DECREASE DA depletion (6-OHDA) NAc(Core) DA neurons - 65
D2 Antagonist infusion NAc(Core) - - 66
Developmental D2R-OE Striatum SPNs WT 57
NOT AFFECTED DA depletion (6-OHDA) NAc(Shell) DA neurons - 67
D2 Antagonist infusion NAc(Shell) - - 66
Viral D2R-OE in adult CPU Untargeted WT 68
Viral D2R-OE in adult NAc Indirect SPNs βarr 69
Viral D2R-OE in adult NAc ChINs WT 43
INCREASED Viral D2R-OE in adult NAc Untargeted WT 68
Viral D2R-OE in adult NAc Indirect SPNs WT 43
D2R knockout VTA/NAc DA neurons WT 70
D2R shRNA knockdown VTA/NAc DA neurons WT 71