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. 2022 Feb 11;8:59. doi: 10.1038/s41420-022-00842-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A YAP protein level in LUAD and adjacent normal tissues as measured by ELISA. B 6PGL mRNA level in LUAD and adjacent normal tissues as measured by qPCR. C Association between YAP protein and 6PGL mRNA level. D Co-IP experiments analyzing YAP ISGylation in LUAD and adjacent normal tissues, and YAP and 6PGL expression in Input sample were analyzed by IB. The YAP level in each co-IP sample was adjusted to the same protein content. E, F Association between YAP bound ISG15 intensity and YAP intensity (E), as well as YAP, bound ISG15 intensity and 6PGL intensity (F) in LUAD tissues. G, H YAP protein and 6PGL mRNA level in stage I–III LUAD samples (G), <3 cm and >3 cm diameter LUAD samples (H). I Survival analysis for LUAD patients with high or low YAP protein and 6PGL mRNA level. J YAP protein and 6PGL mRNA level in high and low glucose LUAD samples. K Co-IP experiments analyzing YAP ISGylation in high and low glucose LUAD tissues, and YAP and 6PGL expression in Input sample were analyzed by IB. The YAP level in each co-IP samples was adjusted to the same protein content. L, M Association between YAP bound ISG15 intensity and YAP intensity, as well as YAP, bound ISG15 intensity and 6PGL intensity in high (L) or low (M) glucose LUAD tissues. The data are shown as the mean ± SD from three biological replicates (including IB). Data in A, B, H, I were analyzed using a student’s t test. Data in C, E, F, L, M were analyzed using the Spearman rank correlation analysis. Data in G were analyzed using a one-way ANOVA test. Data in I were analyzed using a log-rank test. **P < 0.01.