Fig. 1.

The evolution of BM and MLS across primates. (a) PGLS models correlating MLS ∼ BM across mammals. The highlighted species are from the primate order (orange) and other lineages that have been previously associated with cancer resistance and extreme longevity: bats (green), naked mole rat (NMR, red), cetaceans (dark gray). (b) PGLS correlating MLS ∼ BM across primates. The dashed lines represent a positive correlation between log10-transformed BM and MLS. The continuous line displays the correlation between great apes and other primates. (c) Phylogenomic design. The molecular evolution analysis included 19 mammalian species. The six species highlighted are representatives from the main primate lineages (Catarrhini, Platyrrhini, and Strepsirrhini). For these six species, RNA-seq and ChIP-seq data were publicly available (Trizzino et al. 2017). The colors in the phylogenetic tree reflect the values of MLS and BM in each primate branch respectively, from lowest (red) to highest (blue).