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. 2021 Dec 31;39(2):msab369. doi: 10.1093/molbev/msab369

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© The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Fig. 2. — Examples of genes whose evolution correlated with the evolution of MLS. (a, b) Ingenuity Pathway Analysis for 276 genes whose rates of evolution are positively correlated with the MLS. Panels (a) and (b), respectively, show enriched categories for cancer and developmental pathways. (c) Independent PGLS models were performed in order to evaluate the independent contribution of each gene in the evolution of MLS across primates (PGLS dN/dS ∼ MLS). The dN/dS values were obtained from the branch model in PAML. The genes with a FDR <0.1 were considered statistically significant.