Table 1. CHIC-HS Risk Group and Clinicopathologic Characteristics.
| Characteristics | CHIC-HS risk group, No. (%) | P value | |||
|---|---|---|---|---|---|
| Very low (15) | Low (28) | Inter (23) | High (30) | ||
| Sex | |||||
| Girls | 9 (60) | 11 (39) | 8 (35) | 8 (27) | .18 |
| Boys | 6 (40) | 17 (61) | 15 (65) | 22 (73) | |
| Age at diagnosis, ya | |||||
| <3 | 10 (67) | 25 (89) | 17 (74) | 12 (40) | <.001 |
| 3-8 | 5 (33) | 3 (11) | 6 (26) | 10 (33) | |
| ≥8 | 0 | 0 | 0 | 8 (27) | |
| Serum AFP, ng/mLa | |||||
| ≤100 | 3 (20) | 0 | 0 | 2 (7) | .007 |
| 101-1000 | 3 (20) | 1 (4) | 5 (22) | 1 (3) | |
| >1000 | 9 (60) | 27 (96) | 18 (78) | 27 (90) | |
| PRETEXT stagea | |||||
| I | 10 (67) | 1 (4) | 1 (4) | 1 (3) | <.001 |
| II | 5 (33) | 2 (7) | 2 (9) | 3 (10) | |
| III | 0 | 25 (89) | 14 (61) | 12 (40) | |
| IV | 0 | 0 | 6 (26) | 14 (47) | |
| VPEFRa | |||||
| Negative | 15 (100) | 28 (100) | 5 (22) | 12 (40) | <.001 |
| Positive | 0 | 0 | 18 (78) | 18 (60) | |
| Tumor metastasisa | |||||
| Absent | 15 (100) | 28 (100) | 23 (100) | 11 (37) | <.001 |
| Present | 0 | 0 | 0 | 19 (63) | |
| Histological characteristics | |||||
| Epithelial | 13 (87) | 24 (86) | 19 (83) | 26 (87) | .98 |
| Mixed | 2 (13) | 4 (14) | 4 (17) | 4 (13) | |
| Epithelial subtype | |||||
| Fetal | 4 (27) | 4 (14) | 5 (22) | 2 (7) | .002 |
| Embryonal | 2 (13) | 5 (18) | 6 (26) | 7 (23) | |
| Fetal + embryonal | 5 (33) | 18 (64) | 10 (43) | 10 (33) | |
| HCN-NOS | 0 | 0 | 1 (4) | 9 (30) | |
| Others | 4 (27) | 1 (4) | 1 (4) | 2 (7) | |
| Transplant | |||||
| No | 15 (100) | 22 (79) | 10 (43) | 21 (70) | .002 |
| Yes | 0 | 6 (21) | 13 (57) | 9 (30) | |
| Events | |||||
| No | 15 (100) | 26 (93) | 20 (87) | 9 (30) | <.001 |
| Yes | 0 | 2 (7) | 3 (13) | 21 (70) | |
| Died | |||||
| No | 15 (100) | 27 (96) | 21 (91) | 20 (67) | .002 |
| Yes | 0 | 1 (4) | 2 (9) | 10 (33) | |
Abbreviations: AFP, α-fetoprotein; CHIC-HS, Children’s Hepatic Tumors International Collaboration risk stratification for hepatoblastoma; HCN-NOS, hepatocellular neoplasm not otherwise specified; PRETEXT, pretreatment extent of disease; VPEFR, PRETEXT annotation factors.
SI conversion factor: To convert AFP to micrograms per liter, multiply by 1.
a
These variables were incorporated in CHIC-HS.