Table 2. Univariate Cox Regression Analysis of Survival in the Full Cohort.
| Patient or tumor characteristics | Event-free survival | Overall survival | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| CHIC-HS group | ||||
| Very low or low | 1 [Reference] | <.001 | 1 [Reference] | .001 |
| Intermediate | 3.06 (0.51-18.38) | 4.18 (0.38-46.18) | ||
| High | 23.72 (5.53-101.78) | 15.17 (1.94-118.70) | ||
| Histological characteristics (epithelial vs mixed) | 0.67 (0.23-1.97) | .57 | 0.28 (0.08-1.06) | .10 |
| Epithelial subtype | ||||
| Fetal | 1 [Reference] | .36 | 1 [Reference] | .02 |
| Embryonal | 3.01 (0.79-11.42) | 8.22 (1.01-67.02) | ||
| Fetal + embryonal | 1.22 (0.32-4.62) | 1.63 (0.17-15.77) | ||
| Others | 2.03 (0.41-10.05) | 3.71 (0.34-40.90) | ||
| HCN-NOS | 1.99 (0.45-8.91) | NA | ||
| Epithelial regrouped | ||||
| Fetal with or without Embryonal | 1 [Reference] | .23 | 1 [Reference] | .007 |
| Embryonal | 2.61 (1.05-6.51) | 5.84 (1.71-19.97) | ||
| Other | 1.76 (0.49-6.32) | 2.23 (0.48-14.42) | ||
| HCN-NOS | 1.73 (0.55-5.44) | NA | ||
| Male sex (vs female) | 2.10 (0.84-5.23) | .09 | 1.93 (0.53-7.01) | .32 |
| Transplant (vs no transplant) | 0.8 (0.34-1.90) | .61 | 0.37 (0.08-1.66) | .16 |
Abbreviations: HR, hazard ratio; CHIC-HS, Children’s Hepatic Tumors International Collaboration risk stratification for hepatoblastoma; HCN-NOS, hepatocellular neoplasm, not otherwise specified; NA, not applicable.