Table 3. Multivariable Cox Regression Analysis of Survival in the Full Cohort .
| Patient or tumor characteristics | Event-free survival | Overall survival | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI)a | P value | |
| CHIC-HS group | ||||
| Very low or low | 1 [Reference] | <.001 | 1 [Reference] | <.001 |
| Intermediate | 3.26 (0.54-19.83) | 3.72 (0.33-41.53) | ||
| High | 45.59 (9.39-209.5) | 21.95 (2.76-174.29) | ||
| Epithelial subtype | ||||
| Fetal with or without Embryonal | 1 [Reference] | .004 | 1 [Reference] | <.001 |
| Embryonal | 2.66 (1.02-6.94) | 4.41 (1.28-15.19) | ||
| Other | 2.14 (0.58-7.85) | 2.17 (0.39-12.00) | ||
| HCN-NOS | 0.28 (0.08-0.94) | NA | ||
Abbreviations: HR, hazard ratio; CHIC-HS, Children’s Hepatic Tumors International Collaboration risk stratification for hepatoblastoma; HCN-NOS, hepatocellular neoplasm, not otherwise specified; NA, not applicable.
a
With the small ratio of the number of events to the number of parameters, the HR estimates may be biased and should be interpreted with caution.