Table 4. Multivariable Cox Regression Analysis of Survival in the Subcohort Patients With Pretreatment Tumor Histological Data (n = 84).
| Patient or tumor characteristics | Event-free survival | Overall survival | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI)a | P value | |
| CHIC-HS group | ||||
| Very low or low | 1 [Reference] | <.001 | 1 [Reference] | <.001 |
| Intermediate | 2.69 (0.36-20.23) | 1.99 (0.12-32.83) | ||
| High | 42.62 (8.91-203.90) | 18.78 (2.31-152.84) | ||
| Epithelial subtype | ||||
| Fetal with or without Embryonal | 1 [Reference] | .001 | 1 [Reference] | <.001 |
| Embryonal | 3.28 (1.21-8.90) | 7.12 (1.51-33.52) | ||
| Other | 2.14 (0.44-10.49) | 2.66 (0.23-30.38) | ||
| HCN-NOS | 0.30 (0.08-1.07) | NA | ||
Abbreviations: CHIC-HS, Children’s Hepatic Tumors International Collaboration risk stratification for hepatoblastoma; HR, hazard ratio; HCN-NOS, hepatocellular neoplasm, not otherwise specified; NA, not applicable.
a
With the small ratio of the number of events to the number of parameters, the HR estimates may be biased and should be interpreted with caution.