Table 8.
Effect of crude extracts of Ac. on urinary creatinine and the urinary Na/K ratio of cisplatin-treated rats.
| Urinary Creatinine(mg/dL) | Observation (Day) | |||
|---|---|---|---|---|
| Groups | 0 | 7 | 14 | 21 |
| Alhagi camelorum (Ac) | ||||
| Control | 6.8 ± 0.57 | 7.4 ± 0.43 | 8.8 ± 0.72 | 8.2 ± 0.72 |
| Cis | 6.8 ± 0.57 | 4.2 ± 0.47 (*) | 4.3 ± 0.44 (*) | 3.6 ± 0.44 (*) |
| Cis + Aca | 7.0 ± 0.59 | 5.2 ± 0.45 (&) | 5.8 ±0.47 (&) | 5.5 ± 0.46 (&) |
| Cis + Acb | 6.7 ± 0.46 | 6.3 ± 0.46 (#) | 6.3 ± 0.56 (#) | 7.0 ± 0.39 (#) |
| Urinary Na/K ratio | ||||
| Control | 5.5 ± 0.70 | 4.8 ± 0.70 | 5.5 ± 0.69 | 6.1 ± 0.68 |
| Cis | 7.5 ± 0.60 | 38 ± 3.7 (*) | 43 ± 0.97 (*) | 44 ± 6 (*) |
| Cis + Aca | 8.4 ± 0.90 | 26 ± 3.8 (&) | 10.7 ± 0.95 (&) | 24 ± 3.6 (&) |
| Cis +Acb | 6.3 ± 0.66 | 8.0 ± 0.86 (#) | 6.0 ± 0.67 (#) | 10 ± 1.3 (#) |
Mean ± SEM (n = 6), where Cis is cisplatin (5 mg/kg i.p), Cis + Aca is cisplatin + Alhagi camelorum extract (400 mg/kg/21 days), Cis + Acb is cisplatin + Alhagi camelorum extract (600 mg/kg/21 days. The results are considered significant (*) if p < 0.005. * p < 0.05 vs. normal control, & p < 0.05 vs. cisplatin, and # p < 0.05 vs. cisplatin + Alhagi camelorum on corresponding days.