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Conformations of active and inactive EGFR classified by Zhao et al. (2019) [62]. The crystal structures 1M17 [42] and 3IKA [63] represent class-1 and class-2 of the active conformations, while 1XKK [64], 3GOP [30], 2RF9 [65], and 5HG5 [66] represent class-3, class-4, class-5, and class-6 of the inactive conformations, respectively.
