Table 3.
Pharmacokinetic parameters of CPT-containing liposomes.
| Parameters | Drug in Solution | F4 (Conventional) | F8 (PEG2000, 1:25) (PEGylated) | F12 (PEG5000, 1:25) (PEGylated) |
|---|---|---|---|---|
| AUC 0-last (ng/mL.h) |
34.6 | 64.17 * | 3319.3 ** | 3612.2 ** |
| t1/2 (h) | 0.81 | 3.4 * | 4.3 * | 5.9 ** |
| MRT(h) | 0.9 | 3.79 * | 4.92 * | 6.1 ** |
| Total clearance (ml/min/kg) | 61.2 | 39.3 * | 9.23 ** | 7.57 ** |
| Vd (mL/kg) | 1975.2 | 1833.2 * | 1002.5 ** | 690.5 ** |
| Kel (min−1) | 0.95 | 0.43 * | 0.21 ** | 0.19 ** |
Pharmacokinetic parameters of CPT liposomes and CPT solution following i.v. administration in rabbits. Note: ** denotes p < 0.01, * denotes p < 0.05 when compared with CPT solution (ANOVA followed by post hoc Dunnett’s test).