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. 2022 Jan 22;27(3):727. doi: 10.3390/molecules27030727

Figure 8.

Figure 8

Effects of sitagliptin and gliclazide on ERK phosphorylation and autophagy activation. Phospho-ERK(p-ERK), total ERK(t-ERK), LC3 and Beclin-1 were detected by Western immunoblot with protein-loading control by GAPDH or ɑ-Tubulin. Representative images are shown in (A,B). Band intensity by Western immunoblot was quantitated by ImageLab. Data are shown as mean ± SEM of p-ERK, corrected by t-ERK (C), and as mean ± SEM of LC3 and Beclin-1 (D,E), corrected by corresponding loading control. * p < 0.05, significantly different from chow alone; # p < 0.05, significantly different from HFD.