Table 1.
Univariate analysis of factors determining weight gain in the entire cohort.
| Variable | Not Increased Weight (N = 186) |
Increased Weight (N = 171) |
p Value |
|---|---|---|---|
| Baseline Characteristics | |||
| Sex, male, n (%) | 130 (70) | 108 (63) | 0.21 |
| Age, ys | 62 ± 13 | 61 ± 11 | 0.29 |
| Current smokers, n (%) | 20 (11) | 19 (11) | 0.75 |
| Light Drinkers, n (%) Alcohol intake, g/day |
48 (26) 12 (6–22.5) |
31 (18) 9 (6–12) |
0.26 0.08 |
| BMI, kg/m2 ➢ Normal weight ➢ Overweight ➢ Obese |
28.3 ± 3.9 32 (17) 102 (55) 52 (28) |
28.5 ± 4.7 33 (19) 82 (48) 56 (33) |
0.77 0.41 |
| Hypertension, n (%) | 102 (55) | 94 (55) | 1.00 |
| T2DM, n (%) | 41 (22) | 43 (25) | 0.62 |
| Dyslipidaemia, n (%) | 97 (52) | 92 (54) | 0.91 |
| US steatosis ➢ 1, n (%) ➢ 2, n (%) ➢ 3, n (%) |
87 (47) 71 (39) 28 (15) |
70 (41) 75 (44) 26 (15) |
0.37 |
| FIB-4 <1.3, n (%) | 78 (42) | 77 (45) | 0.65 |
| FIB-4 >2.67, n (%) | 6 (3) | 8 (5) | 0.59 |
| Presence of NASH 1, n (%) | 31 (17) | 39 (23) | 0.11 |
| PNPLA3 2 ➢ GG, n (%) ➢ CG + CC, n (%) |
11 (12) 81 (88) |
23 (24) 73 (76) |
0.04 |
| Lifestyle During Lockdown | |||
| Balanced MD, n (%) | 100 (54) | 72 (42) | 0.005 |
| Regular PA, n (%) | 67 (36) | 43 (25) | 0.03 |
Analysis adjusted for sex, age, balanced diet, regular physical activity during lockdown and PNPLA3 genotype. 1 NASH present in 70 patients, out of 80 biopsies available. 2 Data available in 188 patients (of which 92 did not increase weight, while 96 increased weight after lockdown).