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Hypothetical binding mode of 8 in a ternary complex with DNA and Top1 (derived from PDB ID: 1K4T). 2D-ligand interactions (A), ball-and-stick model (B) and the 3D-ligand interactions (C) of 8 and the accepter in the binding pocket. All distances are measured from heavy atom to heavy atom. The carbon atoms of 8 are shown in purple, and the base pairs are displayed as blue lines.
