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Macroscopic and histological evaluations of young and aged ovaries. (a) Representative macroscopic images illustrating young (left panel) and aged ovaries (right panels); (b) 3–4 mm and 5–8 mm follicle rate observed in young and aged ovaries, *** p < 0.001; (c) H & E staining showed the typical ovarian tissue architecture with primordial, growing and antral follicles, ovarian stroma and vasculature in both young and aged tissues. Scale bars = 100 μm.
