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. 2022 Jan 27;27(3):829. doi: 10.3390/molecules27030829

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) Chemical structure of iboga-like compounds tested on their ability to promote GDNF release. (B) GDNF released by C6 cells after 48 h treatment with compounds shown in Figure 5A at 10 µM concentration. (C) 11 dose-response curve after 48 h treatment. (D) 11′s effect on cell lysis determined by LDH assay. (E) 11′s effect on cell viability determined by WST-1 assay. (F) 15′s dose-response curve after 48 h treatment. (G) 15′s effect on cell lysis determined by LDH assay. (H) 15′s effect on cell viability determined by WST-1 assay. Statistics: data represent mean ± SEM of 3 biological replicates. One-way ANOVA followed by Dunnett’s multiple comparisons test is shown (* p < 0.05, *** p < 0.001, **** p < 0.0001).