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. 2022 Feb 3;27(3):1049. doi: 10.3390/molecules27031049

Figure 2.

Figure 2

Effects of coffee-derived circulating metabolites against OGD/ogR-mediated oxidative stress. RBE4 cells pretreated or not for 24 h with 100 nM coffee-derived metabolites were subjected to oxygen and glucose deprivation and subsequent restoration of normoxic and normoglucidic conditions OGD/ogR exposure (A) Cell viability evaluated by MTT assay. (B) ROS intracellular evaluation by DCF fluorescence intensity. The histograms, obtained from three distinct experiments, are expressed as a percentage of cell viability or intracellular ROS as mean ± S.E. * p < 0.05, ** p < 0.01, *** p < 0.001 versus CTRL (untreated cells); §§§ p < 0.001 versus ogR0h; ### p < 0.001 versus to ogR1h.