Table 2.
Characteristics of obese patients with type 2 diabetes mellitus before and 1 year after gastric bypass between the complete remitters of diabetes mellitus (DM-CR) and non-complete remitters of diabetes mellitus (DM-non-CR).
| M0 | M12 | |||||
|---|---|---|---|---|---|---|
| DM-CR (n = 13) |
DM-Non-CR (n = 22) |
p Value | DM-CR (n = 13) |
DM-Non-CR (n = 22) |
p Value | |
| Metabolic profile | ||||||
| Body weight (kg) | 93.85 ± 16.25 | 79.42 ± 9.53 | 0.010 | 62.6 ± 7.78 | 64.43 ± 6.38 | 0.511 |
| BMI (kg/m2) | 34.73 ± 5.00 | 29.79 ± 3.27 | 0.001 | 24.88 ± 4.08 | 24.20 ± 1.64 | 0.641 |
| Waist circumference (cm) | 108.69 ± 10.22 | 100.45 ± 9.13 | 0.020 | 80.56 ± 4.61 | 83.13 ± 5.51 | 0.234 |
| ABSI | 0.080 ± 0.006 | 0.082 ± 0.004 | 0.246 | 0.076 ± 0.006 | 0.078 ± 0.003 | 0.584 |
| Systolic blood pressure (mmHg) | 130.92 ± 13.45 | 139.14 ± 15.07 | 0.115 | 124.00 ± 20.70 | 128.00 ± 14.91 | 0.624 |
| Diastolic blood pressure (mmHg) | 83.54 ± 10.82 | 86.73 ± 10.75 | 0.404 | 75.33 ± 14.07 | 81.0 ± 14.29 | 0.389 |
| Laboratory data | ||||||
| Creatinine (mg/dL) | 0.67 ± 0.15 | 0.86 ± 0.37 | 0.051 | 0.60 ± 0.11 | 0.76 ± 0.33 | 0.063 |
| Fasting blood glucose (mg/dL) | 164.69 ± 64.95 | 183.73 ± 74.34 | 0.449 | 89.70 ± 10.22 | 125.18 ± 31.18 | <0.001 |
| HbA1c (%) | 8.51 ± 1.42 | 9.76 ± 1.41 | 0.016 | 5.42 ± 0.38 | 7.09 ± 0.99 | <0.001 |
| C-peptide (mg/dL) | 3.23 ± 1.01 | 2.31 ± 1.18 | 0.026 | 1.35 ± 0.34 | 1.41 ± 0.57 | 0.791 |
| Insulin (mU/L) | 18.05 ± 9.24 | 26.19 ± 35.75 | 0.321 | 4.99 ± 3.07 | 6.24 ± 8.11 | 0.645 |
| HOMA-IR index | 7.21 ± 3.95 | 11.51 ± 16.55 | 0.256 | 1.06 ± 0.67 | 1.93 ± 2.38 | 0.152 |
| HOMA-β index | 0.81 ± 0.59 | 1.34 ± 2.41 | 0.331 | 0.61 ± 0.64 | 0.44 ± 0.69 | 0.479 |
| ALT (U/L) | 56.08 ± 40.45 | 33.05 ± 25.90 | 0.047 | 24.40 ± 17.56 | 37.52 ± 38.16 | 0.200 |
| AST (U/L) | 37.00 ± 27.61 | 29.32 ± 28.61 | 0.443 | 22.70 ± 12.05 | 31.86 ± 30.52 | 0.371 |
| Alk-p (U/L) | 64.46 ± 24.37 | 59.68 ± 15.55 | 0.482 | 62.70 ± 16.57 | 73.19 ± 20.18 | 0.164 |
| γ-GT (U/L) | 51.58 ± 34.04 | 36.42 ± 22.19 | 0.143 | 12.40 ± 5.30 | 31.45 ± 24.71 | 0.003 |
| Total cholesterol (mg/dL) | 186.62 ± 49.00 | 197.73 ± 39.54 | 0.468 | 155.50 ± 24.65 | 173.82 ± 35.50 | 0.151 |
| Triglyceride (mg/dL) | 179.08 ± 133.37 | 262.27 ± 252.47 | 0.212 | 74.00 ± 24.10 | 119.45 ± 46.79 | 0.001 |
| HDL-C (mg/dL) | 39.85 ± 7.71 | 42.59 ± 7.85 | 0.322 | 45.80 ± 7.94 | 46.55 ± 11.28 | 0.852 |
| LDL-C (mg/dL) | 119.46 ± 39.61 | 116.95 ± 31.00 | 0.836 | 95.10 ± 19.71 | 110.50 ± 33.34 | 0.187 |
| Uric acid (mg/dL) | 5.69 ± 1.58 | 5.61 ± 1.69 | 0.886 | 4.63 ± 1.18 | 5.33 ± 1.61 | 0.230 |
| Total bile acid (µM) | 9.97 ± 3.63 | 10.13 ± 4.77 | 0.919 | 7.61 ± 2.91 | 8.72 ± 5.86 | 0.462 |
| FGF 19 (pg/mL) | 63.73 ± 40.17 | 96.29 ± 68.93 | 0.131 | 162.41 ± 131.83 | 131.03 ± 77.10 | 0.445 |
| FGF 21 (pg/mL) | 370.14 ± 300.53 | 290.47 ± 195.89 | 0.348 | 221.17 ± 93.30 | 235.60 ± 140.44 | 0.744 |
| HSI | 51.30 ± 5.05 | 42.69 ± 4.75 | <0.001 | 36.08 ± 3.10 | 36.33 ± 2.44 | 0.831 |
ABSI, a body shape index; BMI, body mass index; HbA1c, hemoglobin A1c; HOMA, homeostasis model assessment; IR, insulin resistance; ALT, alanine aminotransferase; AST, aspartate transaminase; Alk-p, alkaline phosphatase; γ-GT, gamma-glutamyl transferase; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; FGF, fibroblast growth factor; HSI, hepatic steatosis index.