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Pharmacokinetics parameters of ophthalmic CPX- CLBF (A3) and commercial one (mean ± SD, n = 3.0).
| Parameters | A3 | Commercial CPX |
|---|---|---|
| Dose (µg) | 115 | 150 |
| Cmax (µg/mL) | 4.2 ± 0.1 | 2.7 ± 0.1 |
| Tmax (h) | 2 | 2 |
| K (h−1) | 0.2 ± 0.03 | 0.4 ± 0.01 |
| t1/2 (h) | 3.5 ± 0.2 | 1.7 ± 0.2 |
| AUC 0–t (µg.h/mL) | 34.9 ± 2.1 | 12 ± 0.5 |
| Relative bioavailability | 2.9 | - |
Cmax: maximum plasma concentration; Tmax: time to reach Cmax; K: elimination rate constant; t1/2: half-life; AUC0–t: area under curve from time 0 to t.
