Table 2.
Inhibition rates at 50 μM (%) of compounds 2 and 3a–3k in three cancer cell lines. (The treatment time used in cytotoxicity studies is 48 h).
Compounds | MCF-7 | HepG2 | HeLa |
---|---|---|---|
2 | 26 ± 6 | 54 ± 2 | 20 ± 1 |
3a | 30 ± 2 | 52 ± 1 | 31 ± 7 |
3b | 25 ± 2 | 46 ± 2 | 33 ± 7 |
3c | 28 ± 2 | 30 ± 5 | 26 ± 2 |
3d | 15 ± 7 | 44 ± 1 | 25 ± 2 |
3e | 68 ± 2 | 63 ± 0 | 70 ± 1 |
3f | 77 ± 1 | 69 ± 1 | 74 ± 0 |
3g | 52 ± 1 | 48 ± 2 | 45 ± 2 |
3h | 23 ± 1 | 41 ± 5 | 22 ± 2 |
3i | 36 ± 7 | 53 ± 1 | 53 ± 2 |
3j | 19 ± 2 | 39 ± 7 | 32 ± 4 |
3k | 56 ± 1 | 63 ± 2 | 61 ± 3 |
Cisplatin | 78 ± 1 | 86 ± 1 | 82 ± 1 |