Figure 1.

An illustration of the basic schematic of the Systematic Evolution of Ligands by Exponential Enrichment (SELEX) process. The random library of oligonucleotides is subjected to alternate incubation cycles with the target of interest and counter (negative) targets. The process is typically repeated up to 15 times to increase the binding affinity and specificity of the oligonucleotide library. The final enriched library may contain one or more candidate aptamers. The figure was created with BioRender.com.