TABLE 1.
Origin, grouping according to genotypes, resistance phenotypes, and particular resistance genes in quinupristin-dalfopristin-resistant S. aureusa
| Origin (hospital) | SmaI pattern | No. of isolates | Resistance phenotype | MIC (mg/liter)
|
Streptogramin resistance genes | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| VAN | TEC | LNZ | Q-D | QUI | DAL | |||||
| Paris (Salpetriene) | A | 1 | PEN, OXA, CIP, MXF, Q-D | 0.5 | 0.5 | 1.0 | 8 | 16 | 32 | vat(A), vgb(A) |
| Paris (St. Joseph) | A | 1 | PEN, OXA, GEN, ERY, CLI, OTE, SXT, CIP, MXF, RIF | 0.5 | 0.5 | 1.0 | 2 | 32 | 2 | |
| A | 1 | PEN, OXA, GEN, ERY, CLI, OTE, SXT, CIP, MXF, RIF, Q-D | 0.5 | 0.5 | 1.0 | 8 | 64 | 32 | vat(A), vgb(A) | |
| Lyon | B | 1 | PEN, OXA, PHO, GEN, ERY, CLI, OTE, SXT, CIP, MXF, RIF, Q-D | 0.5 | 0.5 | 0.5 | 8 | 64 | 32 | vat(B), vga(B) |
| Lille | C | 2 | PEN, OXA, GEN, ERY, CLI, OTE, CIP, MXF, SXT, RIF, FUS, Q-D | 2.0 | 2.0 | 0.5 | 8 | 64 | 32 | vat(B), vgaB |
| D | 6 | PEN, OXA, GEN, ERY, CLI, OTE, CIP, MXF, SXT, RIF, FUS, Q-D | 2.0 | 2.0 | 0.5 | 8 | 64 | 32 | vat(B), vga(B) | |
| D1 | 1 | PEN, OXA, GEN, ERY, CLI, OTE, CIP, MXF, SXT, RIF, FUS, Q-D | 2.0 | 2.0 | 0.5 | 8 | 64 | 32 | vat(B), vga(B) | |
| D2 | 1 | PEN, OXA, GEN, ERY, CLI, OTE, CIP, MXF, SXT, RIF, FUS, Q-D | 2.0 | 2.0 | 0.5 | 8 | 64 | 32 | vat(B), vga(B) | |
| E | 7 | PEN, OXA, GEN, ERY, CLI, OTE, CIP, MXF, SXT, RIF, FUS, Q-D | 2.0 | 2.0 | 0.5 | 8 | 64 | 32 | vat(B), vga(B) | |
| E1 | 1 | PEN, OXA, GEN, ERY, CLI, OTE, CIP, MXF, SXT, RIF, FUS, Q-D | 2.0 | 2.0 | 0.5 | 8 | 64 | 32 | vat(B), vga(B) | |
| F | 2 | PEN, OXA, GEN, ERY, CLI, CIP, MXF, Q-D | 2.0 | 2.0 | 0.5 | 8 | 64 | 32 | vat(B), vga(B) | |
| G | 1 | PEN, OXA, GEN, ERY, CLI, OTE, CIP, MXF, SXT, FUS, RIF, Q-D | 2.0 | 2.0 | 0.5 | 8 | 64 | 32 | vat(B), vga(B) | |
| G | 2 | PEN, OXA, GEN, OTE, CIP, MXF, SXT, FUS, RIF | 2.0 | 2.0 | 0.5 | 2 | 8 | 32 | vat(B), vga(B) | |
| G | 2 | PEN, OXA, GEN, ERY-ind., OTE, CIP, MXF, SXT, FUS, RIF | 2.0 | 2.0 | 0.5 | 2 | 8 | 32 | vat(B), vga(B) | |
| H | 2 | PEN, OXA, ERY, CLI, OTE, CIP, MXF, Q-D | 0.5 | 0.5 | 0.5 | 2 | 8 | 32 | vat(B), vga(B) | |
| I | 1 | ERY, Q-D | 0.5 | 0.5 | 0.5 | 4 | 16 | 16 | vat(B), vga(B) | |
| Seville | J | 1 | PEN, ERY, CLI, CIP, MXF, Q-D | 0.5 | 0.5 | 0.5 | 4 | 32 | 32 | |
a
PEN, penicillin G; OXA, oxacillin; CIP, ciprofloxacin; MXF, moxifloxacin; Q-D, quinupristin-dalfopristin (Synercid); GEN, gentamicin; ERY, erythromycin; ERY-ind., inducible erythromycin resistance; CLI, clindamycin; OTE, oxytetracycline; SXT, trimethoprim-sulfamethoxazole; RIF, rifampin; FUS, fusidic acid; VAN, vancomycin; TEC, teicoplanin; LNZ, linezolid; QUI, quinupristin; DAL, dalfopristin.