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. 2022 Jan 20;27(3):674. doi: 10.3390/molecules27030674

Figure 2.

Figure 2

Synthesis, design, and mechanism of the surface charge switchable α-CD-Ce6-NO-DA, which carried a negative surface charge at pH 7.4, but positive surface charge at pH 5.5, in turn promoting efficient penetration of the supramolecular nanocarrier into biofilm. NO is released from α-CD-Ce6-NO-DA upon reaction with biofilm GSH, which depletes biofilm GSH. ROS is generated upon 660 nm laser irradiation, which could react with NO and further improve PDT efficiency. Reproduced with permission from [134].