Table 5.
Drug release kinetics.
| Ist-Order Kinetic | Zero-Order Kinetic | Hixon Crowell’s Erosion Model | Highuchi Diffusion Model | Power Law | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| k1 ± SD | r2 | k2 ± SD | r2 | k3 ± SD | r2 | k4 ± SD | r2 | k5 ± SD | r2 | N |
| Losartan Potassium + Ethocel 100P + Carbopol 934P NF (10:3) Controlled Release Matrices | ||||||||||
| −0.354 ± 0.43 | 0.884 | 7.387 ± 0.37 | 0.986 | 0.356 ± 0.43 | 0.942 | 7.654 ± 0.54 | 0.987 | 0.012 ± 0.03 | 0.973 | 0.682 |
| Losartan Potassium + Ethocel 100FP + Carbopol 934P NF (10:3) Controlled Release Matrices | ||||||||||
| −0.395 ± 0.28 | 0.871 | 8.525 ± 0.31 | 0.990 | 0. 457 ± 0.28 | 0.897 | 7.786 ± 0.58 | 0.992 | 0.013 ± 0.44 | 0.945 | 0.633 |
| Losartan Potassium + Ethocel 100P + Carbopol 934P NF (10:4) Controlled Release Matrices | ||||||||||
| −0.351 ± 0.37 | 0.873 | 7.783 ± 0.23 | 0.994 | 0.293 ± 0.26 | 0.883 | 6.758 ± 0.69 | 0.991 | 0.016 ± 0.08 | 0.939 | 0.626 |
| Losartan Potassium + Ethocel 100FP + Carbopol 934P NF (10:4) Controlled Release Matrices | ||||||||||
| −0.393 ± 0.38 | 0.789 | 7.988 ± 0.66 | 0.992 | 0.289 ± 0.26 | 0.845 | 6.657 ± 0.55 | 0.994 | 0.018 ± 0.26 | 0.942 | 0.734 |
| Losartan Potassium + Ethocel 100P + Carbopol 934P NF (10:5) Controlled Release Matrices | ||||||||||
| −0.379 ± 0.30 | 0.863 | 8.355 ± 0.34 | 0.986 | 0.276 ± 0.53 | 0.990 | 7.769 ± 0.365 | 0.983 | 0.028 ± 0.18 | 0.988 | 0.957 |
| Losartan Potassium + Ethocel 100FP + Carbopol 934P NF (10:5) Controlled Release Matrices | ||||||||||
| −0.186 ± 0.31 | 0.681 | 8.768 ± 0.54 | 0.988 | 0.264 ± 0.59 | 0.978 | 7.786 ± 0.53 | 0.986 | 0.073 ± 0.29 | 0.986 | 0.895 |
| Losartan Potassium and Ethocel 100 Premium + Carbopol 934P NF (10:5) Controlled Release Matrices with HPMC | ||||||||||
| −0.131 ± 0.16 | 0.776 | 2.347 ± 0.11 | 0.782 | 0.116 ± 0.13 | 0.728 | 2.276 ± 0.75 | 0.789 | 0.039 ± 0.01 | 0.875 | 0.758 |
| Losartan Potassium and Ethocel 100FP Premium + Carbopol P934 NF (10:5) Controlled Release Matrices with HPMC | ||||||||||
| −0.173 ± 0.12 | 0.889 | 3.269 ± 0.66 | 0.898 | 0.198 ± 0.17 | 0.862 | 2.382 ± 0.63 | 0.894 | 0.054 ± 0.04 | 0.849 | 0.766 |
| Losartan Potassium and Ethocel 100 Premium + Carbopol 934P NF (10:5) Controlled Release Matrices with CMC | ||||||||||
| −0.145 ± 0.16 | 0.888 | 4.354 ± 0.34 | 0.968 | 0.235 ± 0.25 | 0.881 | 3.661 ± 0.28 | 0.956 | 0.016 ± 0.02 | 0.987 | 0.694 |
| Losartan Potassium and Ethocel 100FP Premium + Carbopol 934P NF (10:5) Controlled Release Matrices with CMC | ||||||||||
| −02873 ± 0.16 | 0.769 | 3.775 ± 0.36 | 0.982 | 0.143 ± 0.11 | 0.987 | 3.268 ± 0.76 | 0.984 | 0.041 ± 0.01 | 0.989 | 0.779 |
| Losartan Potassium and Ethocel 100 Premium + Carbopol 934P NF (10:5) Controlled Release Matrices with Starch | ||||||||||
| −0.298 ± 0.13 | 0.879 | 2.354 ± 0.55 | 0.980 | 0.176 ± 0.12 | 0.985 | 3.721 ± 0.27 | 0.979 | 0.045 ± 0.01 | 0.976 | 0.737 |
| Losartan Potassium and Ethocel 100FP Premium + Carbopol 934P NF (10:5) Controlled Release Matrices with Starch | ||||||||||
| −0.292 ± 0.78 | 0.889 | 4.359 ± 0.22 | 0.985 | 0.154 ± 0.11 | 0.978 | 3.481 ± 0.25 | 0.972 | 0.049 ± 0.18 | 0.984 | 0.854 |