Table 4.
Comparison of hematological and iron status at baseline and during the follow-up by supplementation.
| Iron Status | Baseline | 3 Months after Supplementation | 6 Months after Supplementation | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Ferrous Bisglycinate Plus Folinic Acid | Control | P | Ferrous Bisglycinate Plus Folinic Acid | Control | P | Ferrous Bisglycinate Plus Folinic Acid | Control | P | |
| Hb (g/dL) | 10.04 ± 0.83 | 10.17 ± 0.77 | 0.415 | 12.40 ± 0.68 | 11.78 ± 0.72 | <0.001 | 12.82 ± 0.66 | 12.09 ± 0.60 | <0.001 |
| Mean Change | 2.356 ± 0.69 | 1.61 ± 0.838 | <0.001 | 2.78 ± 0.822 | 1.92 ± 0.89 | <0.001 | |||
| Erythrocytes (×1012/L) | 2.23 ± 0.42 | 2.11 ± 0.30 | 0.066 | 3.93 ± 0.437 | 3.23 ± 0.36 | <0.001 | 4.22 ± 0.30 | 3.41 ± 0.317 | <0.001 |
| Mean Change | 1.69 ± 0.581 | 1.12 ± 0.33 | <0.001 | 1.98 ± 0.49 | 1.30 ± 0.35 | <0.001 | |||
| Reticulocytes (×109/L) | 45.98 ± 4.53 | 43.15 ± 4.15 | 0.051 | 63.71 ± 6.69 | 55.77 ± 3.88 | <0.001 | 69.91 ± 6.32 | 57.70 ± 4.48 | <0.001 |
| Mean Change | 17.73 ± 7.99 | 12.62 ± 4.03 | <0.001 | 23.93 ± 8.12 | 14.55 ± 5.02 | <0.001 | |||
| MCV (fL) | 72.76 ± 3.77 | 70.38 ± 3.67 | 0.061 | 79.55 ± 3.70 | 75.81 ± 3.01 | <0.001 | 81.75 ± 3.37 | 78.91 ± 3.38 | <0.001 |
| Mean Change | 6.78 ± 4.45 | 5.43 ± 3.00 | 0.067 | 8.98 ± 4.72 | 8.53 ± 4.24 | 0.601 | |||
| MCH (pg) | 26.84 ± 3.19 | 25.59 ± 2.54 | 0.059 | 33.73 ± 1.83 | 30.06 ± 2.04 | <0.001 | 34.64 ± 1.52 | 31.35 ± 2.00 | <0.001 |
| Mean Change | 4.8 ± 2.489 | 3.905 ± 1.757 | 0.033 | 5.909 ± 2.619 | 4.981 ± 2.240 | 0.051 | |||
| MCHC (g/dL) | 26.84 ± 3.19 | 25.59 ± 2.54 | 0.059 | 33.73 ± 1.83 | 30.06 ± 2.04 | <0.001 | 34.64 ± 1.52 | 31.35 ± 2.00 | <0.001 |
| Mean Change | 6.89 ± 3.51 | 4.46 ± 1.86 | <0.001 | 7.81 ± 3.49 | 5.76 ± 2.98 | 0.002 | |||
| Transferrin Saturation (%) | 19.90 ± 3.62 | 20.68 ± 2.88 | 0.1598 | 34.78 ± 3.92 | 28.96 ± 1.92 | <0.001 | 36.47 ± 3.59 | 30.08 ± 2.11 | <0.001 |
| Mean Change | 14.88 ± 3.62 | 8.28 ± 3.457 | <0.001 | 16.58 ± 3.76 | 9.40 ± 3.43 | <0.001 | |||
| Ferritin (µg/L) | 25.63 ± 3.128 | 23.90 ± 3.31 | 0.060 | 38.70 ± 4.04 | 30.12 ± 2.91 | <0.001 | 40.45 ± 3.13 | 31.02 ± 1.70 | <0.001 |
| Mean Change | 13.077 ± 2.886 | 6.218 ± 1.86 | <0.001 | 14.78 ± 3.305 | 7.119 ± 3.18 | <0.001 | |||
Values are means ± SD. P = Comparison of means between the two groups; significant differences at p < 0.05. Hb = Hemoglobin, MCV = Mean corpuscular volume, MCH = Mean corpuscular hemoglobin, MCHC = Mean corpuscular hemoglobin concentration.