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. 2022 Jan 28;15(3):1041. doi: 10.3390/ma15031041

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Genetic control of chitin matrix formation in Drosophila melanogaster. The chitin-binding protein Obst-A (CPAP3-A) operates as a hub for chitin matrix formation. Within the assembly zone, Obst-A recruits chitin to a scaffold where it places chitin deacetylases (Serp and Verm) and Knickkopf for chitin matrix assembly and maturation into nanofibrils and the subsequent accumulation into compact fibers of the chitinous procuticle. Obst/CPAP family members act synergistically in this process. The genes and their discussed products, the hub of chitin matrix formation, are evolutionarily conserved among arthropods, indicating their general necessity for cuticle biology.