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. 2022 Feb 8;27(3):1142. doi: 10.3390/molecules27031142

Table 3.

Sesquiterpene lactones and their derivatives with clinical relevance.

Sesquiterpene
Lactone or Derivative		 Clinical Study References/
ClinicalTrals.gov Identifier
Dimethyl-amino-parthenolide (LC-1)
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CAS number: 870677-05-7		 Phase I clinical trials [124]
Artesunate (DB09274)
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CAS number: 80155-81-3		 Advanced breast cancer
High grade vulvar intraepithelial neoplasia
Phase I clinical trials
Phase II/III Colorectal cancer		 NCT00764036 [132]
NCT03792516
NCT04098744
NCT03093129
2’-aminoarteether (β) maleate (SM934)
Inline graphic
CAS number: 133162-25-1		 Licensed drug
Systemic lupus erythematosus		 [138,139,140]
Approved by the China Food and Drug Administration
Mipsagargin (G-202)
Inline graphic
CAS number: 1245732-48-2		 Licensed drug
Advanced solid tumors		 NCT01056029 [143]
https://www.drugbank.ca/drugs/DB11813 (last accessed on 7 January 2022