Figure 3.

Exercise training restores proper blood flow to skeletal muscle and increases insulin. The extracellular matrix becomes less fibrotic, allowing the passage of glucose and insulin to skeletal muscle. Intramuscular glucose metabolism increased, thereby decreasing the allosteric downregulation of glucose disposal and augmentation of the glucose gradient for facilitated glucose transport. Decreased intracellular DAG and toxic lipid accumulation improves post-receptor insulin action. Hexokinase (HK). Phosphokinase B (Akt).