Table 5.

Gene expression profiles of hepatic fibrogenesis in HFD and MCD diet-fed animal models.

Gene Symbol	Nomenclature	Role	Diet Type	Duration (Weeks)	Animal Model	Gene Expression	Reference
ACTA2 (ASMA)	Anti-smooth muscle actin	Activation to myofibroblast-like cell	HFD	25	C57BL/6 mice	Up	[22]
COL1A1	Collagen type 1 alpha 1	Fibrillar forming collagen	HFD	25	C57BL/6 mice	Up	[22]
				24	Male C57BL/6J mice	Up	[45]
			MCD	2	Male SD rats	Up	[51]
				17	Male SD rats	Up	[52]
COL1A2	Collagen type I alpha 2		HFD	24	Male C57BL/6J mice	Up	[45]
COL4A1	Collagen type IV alpha 1		HFD	24	Male C57BL/6J mice	Up	[45]
HGF	Hepatocyte growth factor	Hepatotropic factor, which acts as a growth factor	HFD	25	C57BL/6 mice	Up	[22]
LUM	Lumican	Extracellular matrix structural constituent	HFD	25	C57BL/6 mice	Up	[22]
MMP-13	Matrix metalloproteinase-13	Degradation of extracellular matrix proteins	MCD	2	Male SD rats	Up	[51]
MMP-9	Matrix metalloproteinase-9		MCD	2	Male SD rats	Up	[51]
PAI-1	Plasminogen activator inhibitor 1	Inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU)	HFD	24	Male C57BL/6J mice	Up	[45]
SOCS1	Suppressor of cytokine signaling 1	Prevents uncontrolled cytokine signaling	MCD	2	Male SD rats	Up	[51]
TIMP-1	Tissue inhibitor matrix metalloproteinase 1 (TIMP Metallopeptidase Inhibitor 1)	Inhibitor of collagenases by forming one to one complexes	MCD	17	Male SD rats	Up	[52]
			HFD	25	C57BL/6 mice	Up	[22]
TGF-β1	Transforming growth factor-beta 1	Acts as a regulator of extracellular matrix storage	HFD	25	C57BL/6 mice	Up	[22]
				24	Male C57BL/6J mice	Up	[45]