Scheme 1.
(i) KOH or NaOH, CHBr3 or CHCl3, room temperature, 16–36 h; (ii) MeOH, H2SO4, reflux, 4 h; (iii) Phenylboronic acid, Cs2CO3, Pd[(C6H5)3P]4, anhydrous toluene, reflux, 8 h; (iv) 2 N NaOH, THF, room temperature, overnight.
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