Table 3.

Biological properties of compounds 3–11: inhibition of AChE and self-mediated Aβ₄₀ aggregation.

Compound	AChE	Aβ40 Aggr.
	i% @10 µM a	i% @100 µM a
3	39 ± 5	29 ± 4
4	49 ± 1	25 ± 5
5	n.t.	n.t.
(S)-5	37 ± 5	37 ± 5
(R)-5	37 ± 3	39 ± 3
6	44 ± 4	17 ± 2
7	n.t.	n.t.
8	n.t.	n.t.
9	n.t.	n.t.
10	35 ± 1	25 ± 6
11	n.t.	n.t.
(S)-11	47 ± 3	35 ± 4
(R)-11	38 ± 4	44 ± 4
Donepezil	0.017 ± 0.002 b	14 ± 7 c

^a Percent of inhibition at the reported concentration; ^b this value corresponds to the IC₅₀ of donepezil; ^c percent of inhibition at 10 μM [46]; n.t.: not tested.