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. 2022 Feb 11;22:74. doi: 10.1186/s12935-022-02496-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Canagliflozin inhibited thyroid cancer growth in vivo. A The representative image of xenografts. B Tumor weights of canagliflozin treatment group were smaller than those treatment with blank solvent. The xenograft tumors were dissected to detect the weights at 35 days after transplantation. A t-TEST was used to determine statistical significances. C The growth curve of subcutaneous xenograft tumor from TPC-1 cells in nude mice. Tumor size was measured every 2 days. Repeated-measures analysis of variance was used to determine statistical significances. D The body weights of mice administrated with canagliflozin or blank solvent throughout the experimental period. Repeated-measures analysis of variance was used to determine statistical significances. E Canagliflozin had no effect of fasting blood glucose in mice with thyroid cancer allografts. A t-TEST was used to determine statistical significances. F. Ki67 staining of thyroid carcinoma xenografts. G Tunel staining of thyroid carcinoma xenografts