Figure 2.

The common and specific core signaling pathways for lean and obese PCa. This figure summarizes the genetic and epigenetic carcinogenic mechanisms of lean and obese PCa. The signaling pathways in the deep blue region are the common core signaling pathways of lean and obese PCa. The light green region represents specific core signaling pathways of lean PCa. The brown region denotes specific core signaling pathways of obese PCa. The black arrow heads of solid lines denote activation of TF, miRNA, target genes, and cellular functions; the black circle heads of solid lines refer to inhibition of TF, miRNA, target genes, and cellular functions; the black up arrows signify high expression of protein, receptor, TF, and target genes; the black down arrows indicate low expression of protein, receptor, TF, and target genes.