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. 2022 Feb 11;22:70. doi: 10.1186/s12886-022-02291-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Mutations and predicted crystal structures of SOX2 protein. A Location of the mutations with respect to the topological model of the SOX2 polypeptide. B Predicted crystal structures of wild-type (left) and mutant (right) SOX2 protein. SOX family member contains a highly conserved HMG domain (in green/purple), with NLSs positioned within the extremities of the HMG domain