Table 2.

The top 20 DEGs after MP exposure.

Gene Name	Description	Log2fc	Q-Value	Biological Process	Function
hutU	urocanate hydratase	−12.08	5.27 × 10−254	Histidine metabolism	Catalyzes the conversion of urocanic acid
C3	Complement component 3	−11.71	2.10 × 10−210	Immune process	Part of the complement system
UGT	glucuronosyltransferase	−11.43	1.25 × 10−181	Glucuronidation process	Making relative enzymes
C1R	Complement component 1, r subcomponent	−11.24	1.66 × 10−164	Immune process	Part of the complement system
MHC1	major histocompatibility complex	−10.96	3.80 × 10−142	Immune process	Making proteins in certain immune system cells
FKBP4	FK506-binding protein 4	−9.89	2.23 × 10−80	Immune process	Signal transduction
HSD11B2	corticosteroid 11-beta-dehydrogenase isozyme 2	−9.57	8.38 × 10−68	Immune process	Modulates intracellular glucocorticoid levels
FMN2	formin 2	−8.90	5.06 × 10−47	Organismal Systems	Development
RAP1GAP	RAP1 GTPase activating protein 1	9.60	8.43 × 10−68	Cancer tumorigenesis	GTPase activator
NRAS	GTPase NRas	9.67	1.35 × 10−70	Cell division	Signal transduction
RELA	transcription factor p65	9.69	2.28 × 10−71	Inflammatory reaction	Signal transduction
C4	Complement component 4	10.52	6.84 × 10−111	Immune process	Part of the complement system
TACC3	transforming acidic coiled-coil-containing protein 3	10.59	2.30 × 10−115	Cell growth and differentiation	Signal transduction
CAMK1	calcium/calmodulin- dependent protein kinase I	10.61	1.48 × 10−116	Cell growth and death	Signal transduction
TF	transferrin	10.65	2.84 × 10−119	Environmental Information Process	Signal transduction
A2M	alpha-2-macroglobulin	10.79	3.15 × 10−128	Immune process	Proteinase inhibitor
PLAUR	plasminogen activator, urokinase receptor	9.35	3.49 × 10−59	Immune process	Signal transduction
RNF19A	E3 ubiquitin-protein ligase RNF19A	9.25	3.81 × 10−56	Genetic Information Process	Translation
SHOC2	leucine-rich repeat protein SHOC2	9.04	6.74 × 10−50	Environmental Information Process	Signal transduction
ALDH	aldehyde dehydrogenase	8.74	2.74 × 10−42	Metabolism process	Producing aldehyde enzymes