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. 2022 Feb 11;19:47. doi: 10.1186/s12974-022-02388-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Lack of CD36 alters gene expression response in the CP of neonatal mice 3 h after tMCAO. A Venny diagram showing the number of differentially expressed genes (q < 0.05) and the number/percentage of genes shared between different analyses. B Gene clustering and heat map of top 1000 genes significantly (q < 0.05) different between groups. C gProfiler gene ontology graphs and top GO terms related to the green cluster. D Ingenuity Pathway Analysis (IPA) showing a network of pathways and key regulators related to genes in the green cluster and top canonical pathways. Only genes that are significantly different between WT and CD36 KO ipsilateral CP in the green cluster were included in IPA analysis. E gProfiler gene ontology graphs and top GO terms related to the brown cluster. KO CD36 KO, WT wild type, Ipsi ipsilateral, Contra contralateral, CC cellular component, BP biological process, MF molecular function