Table 2.

Numbers of people who died with mention of cryoglobulinemia and hepatitis C virus and those died with mention of cryoglobulinemia and systemic autoimmune disease in the USA, 1999–2018

	1999–2003		2004–2008		2009–2013		2014–2018		1999–2018		2014–2018/2009–2013
	No.	%	No.	%	No.	%	No.	%	No.	%	PMR	95% CI
Cryoglobulinemia with hepatitis C virus
Total	125	32.7	99	32.5	118	39.1	81	26.1	423	32.6	0.67	(0.50–0.89)
Sex
Men	62	36.9	60	44.1	67	45.0	50	35.5	239	40.2	0.79	(0.55–1.14)
Women	63	29.4	39	23.1	51	33.3	31	18.3	184	26.1	0.55	(0.35–0.86)
Age (years)
20–54	74	64.9	55	58.5	23	47.9	11	40.7	163	57.6	0.85	(0.41–1.74)
55–64	19	31.1	28	40.6	70	61.4	41	42.7	158	46.5	0.70	(0.47–1.02)
65+	32	15.5	16	11.3	25	17.9	29	15.5	102	15.1	0.87	(0.51–1.48)
Cryoglobulinemia with autoimmune disease (ICD-10 codes)
Autoimmune disease (M30–M36)	16	4.2	13	4.3	8	2.6	13	4.2	50	3.8	1.58	(0.66–3.82)
Systemic lupus erythematosus (M32)	6	1.6	3	1.0	2	0.7	4	1.3	15	1.2	1.95	(0.36–10.64)
Sjogren’s syndrome (M350)	6	1.6	5	1.6	3	1.0	6	1.9	20	1.5	1.95	(0.49–7.79)
Other autoimmune disease	5	1.3	6	2.0	3	1.0	5	1.6	19	1.5	1.62	(0.39–6.79)
Sex
Men	4	2.4	1	0.7	4	2.7	2	1.4	11	1.9	0.53	(0.10–2.88)
Women	12	5.6	12	7.1	4	2.6	11	6.5	39	5.5	2.49	(0.79–7.82)
Age (years)
20–54	4	3.5	4	4.3	2	4.2	3	11.1	13	4.6	2.67	(0.45–15.96)
55–64	5	8.2	3	4.3	4	3.5	4	4.2	16	4.7	1.19	(0.30–4.75)
65+	7	3.4	6	4.2	2	1.4	6	3.2	21	3.1	2.25	(0.45–11.13)

PMR proportionate mortality ratio, 95% CI 95% confidence interval, ICD-10 codes International Classification of Diseases, Tenth Revision