Table 1.
Selection of Aβ- and tau-associated genes present in both the AlzGene and Alzgset databases that have putative Aplysia gene orthologs. Human gene symbols are mapped to gene name, putative Aplysia ortholog IDs, UniProt accession, Gene Ontology IDs, and Gene Ontology names. Genes represented were annotated for GO BP or MF associated with Aβ or tau, present in the AlzGene and Alzgset gene sets, and annotated to putative Aplysia gene orthologs by BLAST + with an e-value of ≤ 0.0001. Genes of high interest in AD are bolded
| Gene symbol | Gene name | Aplysia gene | UniProt IDs | GO IDs | GO names |
|---|---|---|---|---|---|
| ADAM10 | ADAM metallopeptidase domain 10 |
LOC101859462, LOC101851963, LOC101845373 |
O14672 | GO:0,034,205, GO:0,042,987 | Ab formation, amyloid Precursor protein catabolic process |
| APH1A | aph-1 homolog A, gamma-secretase subunit | LOC101856734 | Q96BI3 | GO:0,034,205, GO:0,042,987, GO:0,042,982 | Ab formation, amyloid precursor protein Catabolic process, amyloid precursor protein metabolic process |
| NCSTN | Nicastrin | LOC100533532 | Q92542 | GO:0,034,205, GO:0,042,987, GO:0,042,982 | Ab formation, amyloid precursor protein catabolic process, amyloid precursor protein metabolic process |
| PSEN1 | Presenilin 1 | LOC100533344 | P49768 | GO:0,034,205, GO:0,042,987, GO:0,042,982 | Ab formation, amyloid precursor protein catabolic process, amyloid precursor protein metabolic process |
| PSENEN | Presenilin enhancer, gamma-secretase subunit | LOC101854684 | Q9NZ42 | GO:0,034,205, GO:0,042,987, GO:0,042,982 | Ab formation, amyloid precursor protein catabolic process, amyloid precursor protein metabolic process |
| DYRK1A | Dual-specificity tyrosine phosphorylation-regulated kinase 1A | LOC106013836 | Q13627 | GO:0,034,205, GO:0,048,156 | Ab formation, tau binding |
| ADRB2 | Adrenoceptor beta 2 |
LOC101855541, LOC101851894, LOC101852650, LOC118478765, Apoa |
P07550 | GO:0,001,540 | Amyloid-beta binding |
| APBB2 | Amyloid-beta precursor protein-binding family B member 2 | LOC101847028 | Q92870 | GO:0,001,540 | Amyloid-beta binding |
| BCHE | Butyrylcholinesterase |
LOC101862164, LOC101860246, LOC101862869, LOC101851188, LOC101856264, LOC101862414, LOC101861954, LOC101846738, LOC101862657, LOC101859867, LOC106013051, LOC101851390, LOC101854068, LOC118479136 |
P06276 | GO:0,001,540 | Amyloid-beta binding |
| CST3 | Cystatin C | LOC101857420 | P01034 | GO:0,001,540 | Amyloid-beta binding |
| EPHA4 | EPH receptor A4 | LOC101861456 | P54764 | GO:0,001,540 | Amyloid-beta binding |
| GRIN2B | Glutamate ionotropic receptor NMDA type subunit 2B | LOC100533244 | Q13224 | GO:0,001,540 | Amyloid-beta binding |
| HSPG2 | Heparan sulfate proteoglycan 2 |
LOC101857847, LOC101859116, LOC101861971, LOC101855448, LOC101847382 |
P98160 | GO:0,001,540 | Amyloid-beta binding |
| LRPAP1 | LDL receptor-related protein associated protein 1 | LOC101847798, LOC101860965 | P30533 | GO:0,001,540 | Amyloid-beta binding |
| NGFR | Nerve growth factor receptor | LOC106012918 | P08138 | GO:0,001,540 | Amyloid-beta binding |
| SORL1 | Sortilin-related receptor 1 |
LOC101857914, LOC118477251, LOC101846105 |
Q92673 | GO:0,001,540 | Amyloid-beta binding |
| TLR4 | Toll-like receptor 4 |
LOC101847817, LOC101850809, LOC101860761 |
O00206 | GO:0,001,540 | Amyloid-beta binding |
| LDLR | Low-density lipoprotein receptor | LOC118478465 | P01130 | GO:0,001,540, GO:0,097,242 | Amyloid-beta binding, Amyloid-beta clearance |
| LRP1 | LDL receptor-related protein 1 |
LOC101849041, LOC101849281, LOC101859513, LOC100533545, LOC118478804, LOC118478805, LOC106013813, LOC106013825 |
Q07954 | GO:0,001,540, GO:0,097,242 | Amyloid-beta binding, Amyloid-beta clearance |
| IDE | Insulin-degrading enzyme | LOC101845820 | P14735 | GO:0,001,540, GO:0,097,242, GO:0,050,435 | Amyloid-beta binding, Amyloid-beta clearance, Amyloid-beta metabolic process |
| BACE1 | Beta-secretase 1 | LOC101859129 | P56817 | GO:0,001,540, GO:0,050,435 | Amyloid-beta binding, Amyloid-beta metabolic process |
| CHRNA7 | Cholinergic receptor nicotinic alpha 7 subunit |
LOC101851082, LOC101856227, LOC101862541, LOC101856484, LOC101852526, LOC101856946, LOC101852974, LOC106012547, LOC106013357, LOC101853763, LOC101845987, LOC101845835, LOC101857864, LOC101858254, LOC101860243, LOC101845238, LOC101845238, LOC101856899, LOC101856899, LOC101858495, LOC101860344, LOC101860583, LOC106012370, LOC101860114, LOC101860352, LOC101853250, LOC101853479, LOC101861149 |
P36544 | GO:0,001,540, GO:1,904,645 | Amyloid-beta binding, response to amyloid-beta |
| PICALM | Phosphatidylinositol-binding clathrin assembly protein | LOC101848715 | Q13492 | GO:0,001,540, GO:0,048,156 | Amyloid-beta binding, tau binding |
| MME | Membrane metalloendopeptidase |
LOC101861636, LOC101853869, LOC101854751 |
P08473 | GO:0,097,242, GO:0,050,435 | Amyloid-beta clearance, Amyloid-beta metabolic process |
| ACE | Angiotensin-converting enzyme I |
LOC101850558, LOC101862115, LOC101849400, LOC101863140 |
P12821 | GO:0,050,435 | Amyloid-beta metabolic process |
| APP | Amyloid-beta precursor protein | LOC118478801, LOC100533426 | P05067 | GO:1,990,000 | Amyloid fibril formation |
| MAPT | Microtubule-associated protein tau | LOC101864325, LOC106010967 | P10636 | GO:1,990,000 | Amyloid fibril formation |
| ABCG1 | ATP-binding cassette subfamily G member 1 | LOC101862516 | P45844 | GO:0,042,987 | Amyloid precursor protein catabolic process |
| DHCR24 | 24-Dehydrocholesterol reductase |
LOC101864542, LOC101864542, LOC101849310 |
Q15392 | GO:0,042,987 | Amyloid precursor protein catabolic process |
| BIN1 | Bridging integrator 1 | LOC101856166 | O00499 | GO:0,048,156 | Tau binding |
| CDK5 | Cyclin-dependent kinase 5 | LOC101853437, LOC101864023 | Q00535 | GO:0,048,156 | Tau binding |
| GSK3B | Glycogen synthase kinase 3 beta | LOC100533534 | P49841 | GO:0,048,156 | Tau binding |
| PIN1 | Peptidyl-prolylcis/trans isomerase, NIMA-interacting 1 | LOC101858155 | Q13526 | GO:0,048,156 | Tau binding |