Table 3.
Gene orthologs downregulated in both Aplysia SN aging and FL LOAD. All genes downregulated in two or more aging Aplysia SN differential expression data sets and five or more in meta-analysis of human frontal lobe FL LOAD samples by Li et al. (2015). See Table 2 for column descriptions. A majority of shared downregulated orthologs are involved in one or more of the following processes: cellular cargo transport, endo/exocytosis, proteostasis, lipid metabolism, energy metabolism, mitochondrial homeostasis, and signaling
| Aplysia RefSeq Transcript | e-value | Human gene symbol | Other names | Aplysia data sets | FL LOAD data sets | Major category |
|---|---|---|---|---|---|---|
| XM_005098930 | 0 | AATM | GOT2 | 3 | 5 | Energy metabolism |
| XM_005099066 | 2.5E-46 | ARF3 | ARF3 | 2 | 6 | Cellular cargo transport |
| XM_005112446 | 2.6E-25 | CISD1 | ZCD1, mitoNEET | 2 | 5 | Energy metabolism |
| XM_013080281 | 3.6E-21 | CNRP1 | C2orf32 | 2 | 6 | Signaling |
| XM_005098434 | 1.3E-59 | CYC | CYCS | 2 | 6 | Energy metabolism |
| XM_005096347 | 3.9E-65 | DCTN6 | WS3 | 2 | 6 | Cellular cargo transport |
| XM_005100966 | 1.1E-107 | DECR2 | PDCR, SDR17C1 | 2 | 5 | Lipid metabolism |
| XM_005092530 | 2.1E-146 | ELAV4 | ELAVL4, HUD, PNEM | 2 | 6 | Synaptic plasticity, mRNA stabilization |
| XM_005112819 | 0 | EXOC8 | EXO84 | 2 | 5 | Exocytosis |
| XM_005097581 | 5.5E-10 | FABPH | FABP3, FABP11, MDGI | 2 | 5 | Lipid metabolism |
| XM_005096727 | 4.0E-41 | GDAP1 | 3 | 5 | Mitochondrial homeostasis | |
| XM_005111161 | 8.8E-44 | GDAP1 | 2 | 5 | Mitochondrial homeostasis | |
| NM_001204703 | 0 | GNAO | GNAO1 | 3 | 6 | Signaling, Ca++ homeostasis |
| XM_005102254 | 0 | GNB5 | 2 | 5 | Signaling, Ca++ homeostasis | |
| XM_005112007 | 0 | HMCS1 | HMGCS1,HMGCS | 2 | 5 | Lipid metabolism, steroid metabolism |
| XM_005104774 | 4.8E-106 | HPRT | HPRT1, HGPRT | 2 | 6 | Nucleotide salvage |
| XM_005102830 | 2.0E-07 | JUPI1 | ARM2, HN1 | 2 | 5 | Other |
| NM_001204491 | 0 | KAPCA | PRKACA, PKACA | 2 | 5 | Synaptic plasticity, Ca++ signaling, phosphorylation |
| XM_005106951 | 4.0E-65 | KCC4 | CAMK4, CAMK, CAMK-GR, CAMKIV | 2 | 5 | Synaptic plasticity, Ca++ signaling, phosphorylation |
| XM_005104905 | 0 | KIFA3 | KIFAP3, KIF3AP, SMAP | 3 | 6 | Cellular cargo transport |
| XM_005102605 | 1.4E-10 | LIAT1 | C17orf97 | 2 | 5 | Other |
| XM_005098563 | 4.0E-171 | MDHC | MDH1, MDHA | 2 | 6 | Energy metabolism |
| XM_005089329 | 0 | MP2K1 | MAP2K1, MEK1, PRKMK1, MKK1, MAPKK1 | 2 | 6 | Synaptic plasticity, phosphorylation |
| XM_005098362 | 3.2E-56 | MPND | MPND | 3 | 5 | Other |
| XM_005089044 | 7.7E-36 | NDUAA | NDUFA10, CI-42kD | 2 | 5 | Energy metabolism |
| XM_005097418 | 0 | NDUV1 | NDUFV1, UQOR1 | 2 | 5 | Energy metabolism |
| XM_005099251 | 2.6E-103 | NECP1 | NECAP1 | 2 | 6 | Endocytosis |
| XM_005097828 | 0 | ODPB | PDHB, PHE1B | 3 | 6 | Energy metabolism |
| XM_013084642 | 3.7E-89 | OTUB1 | OTB1, OTU1 | 3 | 6 | DNA damage response |
| XM_013081831 | 0 | PCCB | 2 | 5 | Lipid metabolism | |
| XM_005089882 | 4.6E-28 | PEX19 | HK33, PXF | 2 | 5 | Lipid metabolism, proteostasis |
| XM_005110189 | 0 | PFKAM | PFKM, PFKA, PFKX | 2 | 6 | Energy metabolism |
| XM_005109909 | 4.9E-74 | PITH1 | PITHD1, C1orf128 | 2 | 5 | Transcription |
| XM_005097948 | 2.5E-50 | PPAC | ACP1, LMW-PTP | 2 | 6 | Phosphorylation |
| XM_005097122 | 4.3E-133 | RAB6A | RAB6 | 2 | 5 | Cellular cargo transport |
| XM_005093164 | 1.7E-87 | SAMC | SLC25A26 | 3 | 5 | Mitochondrial homeostasis |
| XM_005108342 | 9.4E-28 | SCOC | SCOCO | 3 | 6 | autophagy |
| XM_005093202 | 4.4E-78 | SNAG | NAPG, SNAPG | 2 | 6 | Cellular cargo transport, endocytosis |
| XM_013087712 | 1.4E-156 | SNX4 | 3 | 6 | Cellular cargo transport, endocytosis, proteostasis | |
| XM_005091494 | 2.5E-111 | SPEE | SRM, SPS1, SRML1, SPDSY | 3 | 5 | Mitochondrial homeostasis, proteostasis |
| NM_001204727 | 5.4E-129 | STAU2 | STAU2 | 2 | 6 | Cellular cargo transport |
| XM_013086901 | 5.0E-24 | STUM | C1orf95 | 3 | 5 | Other |
| XM_005107969 | 0 | SVOP | 2 | 5 | Exocytosis | |
| NM_001204483 | 2.7E-151 | SYN2 | 2 | 5 | Exocytosis | |
| XM_013090258 | 1.1E-63 | TTPAL | C20orf121 | 2 | 5 | Other |
| XM_005091686 | 3.4E-21 | TUSC2 | C3orf11, FUS1, LGCC, PDAP2 | 2 | 6 | Mitochondrial homeostasis, inflammation, cytokine signaling, ROS response |
| XM_005109532 | 8.7E-119 | 1433Z | YWHAZ, KCIP-1, 14–3-3 protein zeta/delta | 2 | 5 | Signaling, proteostasis |