Table 1.
Estimates of population, efficacy and resource use
| Input | Value | Type | Range or Parameter | Source |
|---|---|---|---|---|
| Estimates of population, efficacy and resource use | ||||
| Sensitivity | ||||
| G-ROP | 100.0 % | Beta distribution | n=4590 r=4589 | (11) |
| CS a | 99.4 % | Beta distribution | n=459 r=456 | (11) |
| Specificity | ||||
| G-ROP | 32.3 % | Beta distribution | n=7024 r=2269 | (11) |
| CS a | 11.8. % | Beta distribution | n=6197 r=827 | (11) |
| Gestational Age (weeks) | 22–32 | Empirical distribution a | (19) | |
| Birth Weight by GA | 400–5000 | Empirical distribution a | (19) | |
| ROP Incidence by GA | 0 – 0.31 | Probability table a | (11) | |
| Time for Examination | ||||
| MD | 14 (SD 7.7) | Normal distribution | mean=14 SD=7.7 | Observation d |
| RN | 15.2 (SD 7.9) | Normal distribution | mean=15.2 SD=7.9 | Observation d |
| Coordinator | 21.9 (SD 8.0) | Normal distribution | mean=21.9 SD=8.0 | Observation d |
| Number of examinations | ||||
| With ROP | 6.1 (SD 2.9) | Normal distribution | mean=6.1 SD=2.9 | (11) |
| Without ROP | 2.6 (SD 1.5) | Normal distribution | mean=2.6 SD=1.5 | (11) |
| Probability of laser photocoagulation | ||||
| If Type 1 detected | 1.0 | Point estimate | NA | Assumption |
| If Type 1 missed | 0 | Point estimate | NA | Assumption |
| Probability of retinal surgery | ||||
| If Type 1 detected | 0.064 | Point estimate | NA | (2) |
| If Type 1 missed | 0.43 | Point estimate | NA | (22) |
| Discount rate | 0.03 | Point estimate | 0.015 – 0.045 | (20) |
| Utility | ||||
| Good visual outcome w/o ROP | 0.97 | Point estimate | NA | (28) |
| Poor visual outcome with ROP | 0.27 | Point estimate | 0.14 – 0.41 | (28) |
| Good visual outcome with ROP | 0.87 | Point estimate | 0.44 – 1.00 | (28) |
| Probability of poor visual outcome | ||||
| Without ROP | 0 | Point estimate | NA | Assumption |
| With ROP detected and treated | 0.143 | Point estimate | 0.143 – 0.198 | (2) |
| With ROP not detected or treated | 0.643 | Point estimate | NA | (3) |
| Estimates of unit cost b | ||||
| Hourly personnel cost | ||||
| Ophthalmologist | 254 | Point estimate | 127 – 381 | (15) |
| RN | 48 | Point estimate | 24 – 72 | (14) |
| Coordinator | 22 | Point estimate | 11 – 33 | (14) |
| Retinal surgery | 13,343 | Point estimate | 6,672 – 20,015 | (16) |
| Laser photocoagulation | 3,114 | Point estimate | 2,180 – 4,048 | (16) |
| Lifetime cost of poor visual outcome | 791,432 | Point estimate | 554,002–1,028,862 | (29) |