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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: Semin Cell Dev Biol. 2021 Oct 30;123:4–13. doi: 10.1016/j.semcdb.2021.10.008

Figure 2. Pathways mediating the coupling of bone resorption and bone formation.

Figure 2.

Centrifuged human bone biopsies were subjected to RNA-sequencing (GSE141614). 555 bone genes were compiled from gene ontology bone gene sets. From this, OC and OB genes downregulated by DMAb were identified. Rank means of the OC and OB gene signatures, respectively, were used to assess correlation across the comprehensive bone gene set. Significant differential gene expression (DMAb vs placebo) or correlation with OC or OB gene signatures is defined as p<0.05. Significant genes were analyze by iPathway Analysis Software (Advaita) to identify pathways significantly affected by DMAb treatment (blue), or pathways correlating with OC (red) or OB (green) gene signatures. Significant pathways are defined as p<0.10. Pathways significantly associated with DMAb differential gene expression and OC and OB gene signatures may indicate pathways associated with the coupling of OC and OB.