Table 1.
Baseline clinical and CPET characteristics in men and women with HFpEF
| Men N=83 | Women N=107 | p-value | ||||
|---|---|---|---|---|---|---|
| Clinical Characteristic | ||||||
| Age, years | 62 (13) | 59 (14) | 0.07 | |||
| Body mass index, kg/m2 | 30.9 (4.9) | 31.3 (7.8) | 0.65 | |||
| Hypertension, n (%) | 85 (75) | 83 (53) | <0.0001 | |||
| Diabetes mellitus, n (%) | 25 (30) | 14 (13) | 0.004 | |||
| Prevalent MI, n (%) | 7 (8) | 3 (2) | 0.08 | |||
| Prevalent AF, n (%) | 27 (33) | 13 (12) | 0.001 | |||
| Paced rhythm, n (%) | 4 (5) | 2 (2) | 0.25 | |||
| Previous HF admission, n (%) | 7 (8) | 8 (8) | 0.81 | |||
| Current smoking, n (%) | 1 (1) | 3 (3) | 0.44 | |||
| Total cholesterol, mg/dL | 160 (37) | 175 (36) | 0.11 | |||
| Laboratory Values | ||||||
| CRP, pg/mL | 2.3 [1.2, 5.2] | 3.2 [1.2, 6.3] | 0.25 | |||
| NT-pro BNP, pg/mL | 86 [39, 404] | 108 [51, 260] | 0.65 | |||
| eGFR, ml/min/1.73m2 | 77 (22) | 83 (30) | 0.17 | |||
| Hemoglobin, g/dL | 14.1 (1.8) | 12.7 (1.5) | <0.0001 | |||
| Pharmacotherapy | ||||||
| Diuretics, n (%) | 38 (46) | 40 (37) | 0.24 | |||
| ACE inhibitor, n (%) | 20 (24) | 18 (17) | 0.21 | |||
| ARB, n (%) | 15 (18) | 10 (9) | 0.08 | |||
| ß-adrenergic blocker, n (%) | 42 (51) | 49 (38) | 0.06 | |||
| Calcium channel blocker, n (%) | 11 (13) | 19 (18) | 0.40 | |||
| Gas Exchange Parameters | ||||||
| Peak VO2, mL/kg/min | 16 (4) | 15 (4) | 0.02 | |||
| % predicted VO2, Jones | 69 (17) | 69 (14) | 0.94 | |||
| VE/VCO2 slope | 36 (9) | 37 (8) | 0.76 | |||
| Max work, watts | 113 (37) | 87 (30) | <0.0001 | |||
| RER, peak | 1.2 (0.11) | 1.2 (0.11) | 0.56 | |||
| Peak C(a-v)O2 | 12.8 (1.9) | 10.8 (1.7) | <0.0001 | |||
| Hemodynamic Parameters | Rest | Peak | Rest | Peak | Prest | Ppeak |
| SBP, mmHg | 150 (21) | 192 (36) | 153 (22) | 192 (25) | 0.44 | 0.88 |
| DBP, mmHg | 77 (13) | 76 (11) | 89 (18) | 92 (17) | 0.67 | 0.18 |
| PP, mmHg | 72 (17) | 103 (24) | 75 (18) | 100 (20) | 0.40 | 0.38 |
| HR, beats/min | 73 (15) | 125 (26) | 78 (13) | 136 (24) | 0.02 | 0.003 |
| PCWP, mmHg | 16 (6) | 25 (7) | 14 (5) | 25 (7) | 0.01 | 0.52 |
| PAP, mmHg | 25 (7) | 42 (9) | 23 (6) | 38 (9) | 0.01 | 0.002 |
| CO, L/min | 5.4 (1.7) | 11.6 (3.4) | 5.0 (1.4) | 10.5 (3.0) | 0.04 | 0.02 |
| CI, L/min/m2 | 2.5 (0.7) | 5.4 (1.3) | 2.7 (0.7) | 5.7 (1.4) | 0.17 | 0.19 |
| PCWP/CO, mmHg/L/min | 2.9 (1.7) | 3.2 (1.8) | 0.16 | |||
| PCWP/CO >2.0 mmHg/L/min, n (%) | 60 (72%) | 86 (80%) | 0.19 | |||
Values are means (standard deviations) or medians [inter-quartile range] unless otherwise noted.
Abbreviations: ACE = angiotensin converting enzyme, ARB = angiotensin receptor blocker, DBP = diastolic blood pressure, MI = myocardial infarction, HF = heart failure, eGFR = estimated glomerular filtration rate, hsCRP = high sensitivity C-reactive protein, IL-6 = interleukin-6, LA = left atrium, LV = left ventricle, NT-pro BNP = N-terminal pro b-type natriuretic peptide, PAP = pulmonary artery pressure, PCWP = pulmonary capillary wedge pressure, RER = respiratory exchange ratio, SBP = systolic blood pressure, TR = tricuspid regurgitation.