Fig. 4.

ASTEX are enriched in mTOR-targeting miRs. ASTEX are enriched in miRs that regulate the mTOR pathway compared to EVs derived from fibroblasts (A; n = 3 biological replicates). Analysis was done using Student's T test. Higher levels of miR-16 in cells treated with ASTEX at 48 h post-treatment (B).Validated targets of miR-10 (pik3ca; C) and miR-16 (dectin-1; D). Analysis was done using One Way ANOVA with Tukey's test for multiple comparisons. *p < 0.05, **p < 0.01, ***p < 0.001 using a 95% CI. Conceptual figure of the mechanism of action of ASTEX in promoting cell survival and inhibiting SARS-CoV-2 viral infection (E).