Table 3.
Association between diabetes status and the length of reproductive period
| Characteristics | Type 1 diabetes (Beta coefficient, 95%CI) |
p-value |
|---|---|---|
| Age at menarche b (n=105, 177) | 0.5 (0.2 to 1.1) | 0.002 |
| Limiting EDC data to women with T1D onset before menarche b (n=80, 177) | 1.0 (0.6 to 1.4) | <0.0001 |
| Limiting EDC data to women with T1D onset after menarche b (n=25, 177) | −0.5 (−1.1 to 0.2) | 0.14 |
| Data adding 18 EDC women b (n=123, 177) a | 0.6 (0.2 to 1.0) | 0.005 |
| Age at natural menopause c (n=103, 176) | −2.0 (−2.9 to −1.0) | <0.0001 |
| Limiting EDC data to women with T1D onset before menarche c (n=78, 176) | −1.8 (−2.7 to −1.0) | <0.0001 |
| Limiting EDC data to women with T1D onset after menarche c (n=25, 176) | −1.0 (−2.1 to 0.1) | 0.08 |
| Including SWAN imputed data c (n=103, 336) | −1.8 (−2.5 to −1.0) | <0.0001 |
| Data adding 18 EDC women c (n=121, 176) a | −1.8 (−2.5 to −1.0) | <0.0001 |
| Reproductive years c (n=103, 176) | −2.5 (−3.6 to −1.5) | <0.0001 |
| Limiting EDC data to women with T1D onset before menarche c (n=78, 176) | −2.9 (−3.8 to −2.0) | <0.0001 |
| Limiting EDC data to women with T1D onset after menarche c (n=25, 176) | −0.7 (−1.9 to 0.6) | 0.29 |
| Including SWAN imputed data c (n=103, 336) | −2.3 (−3.1 to −1.5) | <0.0001 |
| Data adding 18 EDC women c (n=121, 176) a | −2.4 (−3.2 to −1.5) | <0.0001 |
T1D: type 1 diabetes
a
Sensitivity analysis included 18 EDC women who provided self-reported age at natural menopause without sex hormone data prior to the 22-year assessment.
Models were constructed among study participants with complete covariate data
b
Model controlled for race
c
Model controlled for baseline age, race, BMI, smoking status, blood pressure, HDL-C, non-HDL-C, number of pregnancies, and having ever taken oral contraceptives