Fig. 5.

HRSV G-mediated ubiquitination and degradation of GBP5. HRSV glycoprotein G indirectly promotes GBP5 K48 ubiquitination for proteasomal degradation by raising the E3 ligase DZIP3 levels. Degradation of GBP5 increases the formation of HRSV infectious particles. A “U” inside a green circle depicts ubiquitin residues