TABLE 4.
Subgroup analyses for adjusted hazard ratios of outcomes at 12 months according to glucose‐to‐HbA1c ratio quartiles
| Covariate | Level | Death N (%) | Crude results | Adjusted results a | ||||
|---|---|---|---|---|---|---|---|---|
| Odds ratio (95% CI) | p‐value | P for trend b | Odds ratio (95% CI) | p‐value | P for trend b | |||
| History of ischemic stroke | ||||||||
| Glucose‐to‐HbA1c ratio groups | Q1 | 57 (0.34) | – | – | <0.0001 | – | – | 0.0076 |
| Q2 | 65 (0.40) | 1.167 (0.817–1.666) | 0.3961 | 1.207 (0.668–2.183) | 0.5331 | |||
| Q3 | 92 (0.57) | 1.681 (1.207–2.341) | 0.0021 | 1.593 (0.899–2.824) | 0.1109 | |||
| Q4 | 221 (1.33) | 3.938 (2.941–5.273) | <0.0001 | 2.274 (1.176–4.397) | 0.0146 | |||
| MI | ||||||||
| Glucose‐to‐HbA1c ratio groups | Q1 | 14 (1.19) | – | – | <0.0001 | – | – | 0.3871 |
| Q2 | 11 (0.95) | 0.795 (0.359–1.758) | 0.5703 | 0.510 (0.136–1.919) | 0.3196 | |||
| Q3 | 24 (2.39) | 2.034 (1.047–3.954) | 0.0362 | 1.493 (0.437–5.102) | 0.5223 | |||
| Q4 | 42 (3.84) | 3.317 (1.801–6.107) | 0.0001 | 1.499 (0.280–8.013) | 0.6360 | |||
| Hemorrhage | ||||||||
| Glucose‐to‐HbA1c ratio groups | Q1 | 5 (0.47) | – | – | 0.0070 | – | – | 0.0506 |
| Q2 | 4 (0.39) | 0.826 (0.221–3.084) | 0.7759 | 3.253 (0.192–55.201) | 0.4142 | |||
| Q3 | 8 (0.81) | 1.738 (0.567–5.330) | 0.3338 | 1.014 (0.038–26.991) | 0.9935 | |||
| Q4 | 14 (1.42) | 3.042 (1.092–8.477) | 0.0333 | 16.826 (0.771–367.381) | 0.0728 | |||
| Subarachnoid | ||||||||
| Glucose‐to‐HbA1c ratio groups | Q1 | 1 (0.68) | – | – | 0.0513 | – | – | – |
| Q2 | 1 (0.83) | 1.218 (0.075–19.688) | 0.8893 | – | – | |||
| Q3 | 1 (1.00) | 1.465 (0.091–23.693) | 0.7882 | – | – | |||
| Q4 | 4 (3.96) | 5.980 (0.658–54.310) | 0.1121 | – | – | |||
| Reperfusion therapeutic | ||||||||
| Glucose‐to‐HbA1c ratio groups | Q1 | 17 (0.87) | – | – | <0.0001 | – | – | 0.2319 |
| Q2 | 25 (1.14) | 1.313 (0.707–2.439) | 0.3884 | 1.406 (0.513–3.851) | 0.5074 | |||
| Q3 | 48 (2.13) | 2.473 (1.418–4.314) | 0.0014 | 2.911 (1.119–7.572) | 0.0285 | |||
| Q4 | 98 (3.52) | 4.152 (2.473–6.971) | <0.0001 | 2.235 (0.683–7.314) | 0.1838 | |||
| Without a history of previous infarction | ||||||||
| Glucose‐to‐HbA1c ratio groups | Q1 | 52 (0.20) | – | – | <0.0001 | – | – | 0.3870 |
| Q2 | 77 (0.30) | 1.461 (1.027–2.078) | 0.0348 | 1.111 (0.626–1.973) | 0.7188 | |||
| Q3 | 104 (0.40) | 1.956 (1.401–2.729) | <0.0001 | 1.295 (0.727–2.307) | 0.3800 | |||
| Q4 | 214 (0.84) | 4.128 (3.047–5.592) | <0.0001 | 1.369 (0.662–2.831) | 0.3968 | |||
a
Adjusted for age, sex, BMI, NIHSS on admission, hypertension, atrial fibrillation, antiplatelet, anticoagulation, lipid‐lowering drug, smoking, alcohol, LDL‐C, FBG, HbA1c, eGFR, HCY, systolic blood pressure, and diastolic blood pressure.
b
Test for trend based on the variable containing the median value for each quintile.